DNA damage levels in prostate cancer cases and controls
نویسندگان
چکیده
منابع مشابه
DNA damage among thyroid cancer and multiple cancer cases, controls, and long-lived individuals.
Variation in the detection, signaling, and repair of DNA damage contributes to human cancer risk. To assess capacity to modulate endogenous DNA damage among radiologic technologists who had been diagnosed with breast cancer and another malignancy (breast-other, n=42), early-onset breast cancer (early-onset, age <or=35; n=38), thyroid cancer (n=68), long-lived cancer-free individuals (hyper-norm...
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Background: Impaired DNA repair mechanism is one of the main causes of tumor genesis. Study of intrinsic radiosensitivity of cancer patients in a non-target tissue (e.g. peripheral blood) might show the extent of DNA repair deficiency of cells in affected individuals and might be used a predictor of cancer predisposition. Methods: Initial radiation-induced DNA damage (ratio of Tail DNA/Head DN...
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Together with cell cycle checkpoint control, DNA repair plays a pivotal role in protecting the genome from endogenous and exogenous DNA damage. Although increased genetic instability has been associated with prostate cancer progression, the relative role of DNA double-strand break repair in malignant versus normal prostate epithelial cells is not known. In this study, we determined the RNA and ...
متن کاملWhat controls PTEN and what it controls (in prostate cancer).
T he standard of care for metastatic prostate cancer (PCa) is androgen deprivation therapy since almost all PCa growth is initially reliant on the androgen receptor (AR). However, almost all patients develop resistance to this therapy within 18–24 months, and current treatment for castration-resistant prostate cancer (CRPC) is extremely limited, despite the advent of new drugs that target the A...
متن کاملHigher clusterin immunolabeling and sperm DNA damage levels in hypertensive men compared with controls.
BACKGROUND Clusterin, a heterodimeric glycoprotein found at several sites in the human male reproductive tract, could be a marker of morphologically abnormal spermatozoa, while TUNEL positivity indicates DNA fragmentation. Metabolic disorders such as diabetes mellitus and obesity may compromise sperm quality and fertility of men; however, little evidence specifically links hypertension with the...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2005
ISSN: 1460-2180,0143-3334
DOI: 10.1093/carcin/bgi288